Research & News
Stay updated with the latest scientific publications and company announcements
Research Publications
Efficacy of Silicon-Based Membrane in Canine Wound Healing: A Randomized Controlled Trial
Reynolds M, Chen E, Thompson S, et al.
A multicenter randomized controlled trial evaluating the effectiveness of SIOx surgical membrane in promoting wound healing in dogs...
Long-term Outcomes of Synthetic Bone Graft in Feline Fracture Repair
Chen E, Martinez R, Wilson J, et al.
This retrospective study examined the long-term outcomes of SIOx bone graft substitute in 150 feline patients over a 3-year period...
Biocompatibility Assessment of Novel Silicon-Based Biomaterials
Thompson S, Reynolds M, Chen E, et al.
Comprehensive evaluation of biocompatibility and tissue response to a new class of silicon-based biomaterials designed for veterinary applications...
Research & News
FDA 510(k) Clearance of SiOxC® Supports the Skin-Moisture Technology Behind SiOxVet™ Cream
SiOxMed announced that SiOxC® Cream received FDA 510(k) clearance (K242406) as a skin emulsion indicated for management of dry, intact skin by helping maintain a moist skin environment. This clearance represents a key regulatory milestone supporting the underlying skin-moisture retention approach and formulation foundations that inform the development of SiOxVet™ Cream for grooming and skin comfort applications. Supporting evaluations included biocompatibility testing and a Human Repeat Insult Patch Test (HRIPT), with no visible irritation or sensitization responses observed during both induction and challenge phases. (Not for use on breached or compromised skin.)
Coagulopathic Arterial Injury: SiOxVet™ Wound Matrix Preserves Vessel Patency
A peer-reviewed study in Journal of Trauma and Acute Care Surgery evaluated the silica-based fiber matrix technology used in SiOxVet™ Wound Matrix in a coagulopathic swine femoral artery injury model compared to Combat Gauze. Both treatments achieved 100% survival and maintained hemostasis after simulated limb movement, but the matrix showed significantly less blood loss (~106 mL vs 190 mL). Angiography also demonstrated 100% vessel patency and distal perfusion with the matrix, while Combat Gauze–treated arteries were occluded.
Full-Thickness Burn Study: SiOxVet™ Wound Matrix Supports Skin Remodeling
A peer-reviewed study in Military Medicine evaluated the silica-based fiber matrix platform used in SiOxVet™ Wound Matrix in a porcine full-thickness burn model. Researchers observed more mature epidermal structure, improved collagen remodeling, and reduced inflammatory cell infiltration compared to untreated controls. These findings highlight the matrix’s ability to support skin remodeling and tissue response in severe burn injury models.
Severe Liver Injury Model: SiOxVet™ Wound Matrix Achieves Rapid Hemostasis
A peer-reviewed study in Military Medicine evaluated the same silica-based matrix platform used in SiOxVet™ Wound Matrix (reported in the publication as Universal Combat Matrix) in a grade IV swine liver laceration model. The matrix achieved rapid bleeding control (average time to hemostasis ~247 seconds), with 100% survival through 48 hours and no evidence of re-bleeding. Findings supported stable fibrin organization and tissue response consistent with durable hemostasis in severe trauma.
Hemorrhage Control Study: SiOxVet™ Wound Matrix Matches Combat Gauze Performance
A peer-reviewed Journal of Surgical Research study evaluated the silica-based fiber matrix technology used in SiOxVet™ Wound Matrix in a standardized swine femoral artery hemorrhage model. Results showed comparable survival and total blood loss versus QuikClot Combat Gauze, with rapid hemostasis and no exothermic reaction. After simulated limb movement, the matrix showed strong injury-site sealing with 0% contrast extravasation.
FDA 510(k) Clearance of SiOxD® Validates the Technology Platform Behind SiOxVet™ Wound Matrix
SiOxMed announced that SiOxD® Wound Matrix received FDA 510(k) clearance (K222189) for management of a broad range of wound types, including partial- and full-thickness wounds, ulcers, surgical wounds, and trauma wounds. This clearance represents a key regulatory milestone for the synthetic silica-based fiber matrix platform that informs the development of SiOxVet™ Wound Matrix. SiOxD® Wound Matrix is a sterile, non-pyrogenic, absorbent synthetic matrix designed to conform to the wound bed and support a moist wound environment.